Important Safety Information

01What NAD+ is

Nicotinamide adenine dinucleotide (NAD+) is a coenzyme present in every cell in the body. It shuttles electrons in the reactions that convert food into usable energy, and it is consumed by enzymes involved in DNA repair and cellular signalling. Tissue levels measured in humans decline with age.

It is not a hormone, not a peptide, and not a steroid. It is a molecule your body already makes and uses continuously.

02What it is and is not offered for

If you have persistent fatigue, cognitive changes, or unexplained symptoms, those deserve a proper medical workup. Your clinician may tell you to pursue that before anything else, and may decline to prescribe.

03What the evidence supports

Reasonably established

• NAD+ is essential to cellular energy metabolism and to several repair and signalling enzymes.
• Tissue NAD+ concentrations decline with age in humans.
• Oral precursors such as nicotinamide riboside and nicotinamide mononucleotide can raise measurable blood NAD+ levels in small human studies.

Not established

• That raising NAD+ produces a clinical benefit. Higher measured levels have not been shown to translate into better energy, cognition, longevity, or any other outcome in adequately powered human trials.
• That injected NAD+ behaves like the oral precursors that have been studied. Most human data concerns precursors taken by mouth, not NAD+ given by injection.
• Optimal dose, schedule, or duration — none of these have been determined.
• Long-term safety, at any dose.

04Do not use if any of these apply

• You are pregnant, trying to conceive, or breastfeeding. There are no safety data, and that absence is itself the reason.
• You have had a serious hypersensitivity reaction to NAD+ or any ingredient in the preparation.
• You have an active malignancy, unless your treating oncologist has specifically cleared it.
• You are under 18 years of age.

05Warnings and precautions

Cancer — an unresolved question

NAD+ supports the metabolism of every cell, including malignant ones. Some laboratory work suggests NAD+ availability may support tumor growth; other work suggests the opposite in different contexts. This is genuinely unresolved. We do not prescribe during active malignancy, and a prior cancer diagnosis requires oncology clearance.

Infusion- and injection-rate reactions

Flushing, chest tightness, abdominal cramping, nausea, and a racing heartbeat are commonly reported when a dose is given too quickly. They are usually manageable by lowering the dose or slowing the injection.

Unexplained symptoms that have not been worked up

Fatigue, brain fog, and low mood have common and treatable causes — thyroid disease, anemia, iron or B12 deficiency, sleep apnea, depression, diabetes. Starting NAD+ instead of investigating those is a way to delay a diagnosis that matters.

Kidney or liver impairment

Clearance in impaired kidney or liver function has not been characterized. Tell your clinician.

Cardiovascular

Report palpitations, chest pain, or fainting. Tell your clinician about any arrhythmia or low blood pressure before starting.

Sterility and compounding quality

Any injectable carries infection risk if handling is poor. Follow the injection instructions supplied, never reuse needles, and report redness, warmth, swelling, or fever at an injection site.

06Possible side effects

Commonly reported

Injection-site reactions — pain, redness, swelling, itching, or bruising. Rotating sites helps.

Dose- and rate-related effects: flushing, warmth, nausea, abdominal cramping, chest tightness, headache, lightheadedness, and a racing heartbeat. These typically appear during or shortly after a dose and settle within minutes to hours.

Seek medical attention

• Swelling of the face, lips, tongue, or throat; difficulty breathing; a severe rash — possible serious allergic reaction;
• Chest pain, fainting, or a sustained irregular heartbeat;
• Fever, or spreading redness, warmth, or pain at an injection site — possible infection.

This is not a complete list, and because this preparation has no approved labeling, the full side-effect profile is not documented anywhere. Report anything unexpected.

07Drug interactions

Interactions between injected NAD+ and prescription medication have not been systematically studied. That is a real gap rather than a reassurance.

• Give your clinician a complete list of everything you take — prescriptions, over-the-counter medicines, vitamins, herbal products, peptides, and supplements, whatever the source.
• Tell them if you already take an NAD+ precursor such as nicotinamide riboside or nicotinamide mononucleotide, so you are not stacking without knowing it.
• Report any new medication started while you are on treatment.

08Monitoring while on treatment

There is no validated blood test that tells you whether NAD+ therapy is working. Anyone selling you "NAD+ level optimization" against a target number is inventing a precision that does not exist.

What your clinician will actually do:

• Review your symptoms at each check-in, and ask whether anything has changed that they should know about.
• Adjust dose or schedule based on tolerability, not on a lab value.
• Order testing where your history warrants it — thyroid, metabolic panel, iron studies, B12 — usually to look for a treatable cause of your symptoms rather than to monitor the NAD+ itself.
• Stop treatment if it is not helping. Continuing indefinitely without benefit is not a plan.

09Use in specific populations

Pregnancy and breastfeeding

Do not use. There are no data on injected NAD+ in pregnancy or on its presence in human milk. Discuss contraception with your clinician before starting.

Children and adolescents

Reborn Rx treats adults only.

Older adults

NAD+ declines with age, but a decline that comes with normal aging is not by itself a disease to be treated, and treating it has not been shown to change any outcome.

Cancer survivors

Requires documented oncology clearance before treatment can be considered.

Kidney or liver disease

Use with caution; clearance has not been characterized.

10Reporting a side effect

Tell your care team about any side effect, even a minor one. Because this preparation has no approved labeling, patient reports are a meaningful part of how its profile becomes understood.